In-vitro transcription is a molecular method or procedure that allows synthesis of ribosomal nucleic acid (RNA) molecules. In-vitro transcription process enables health care researchers to synthesize different sizes varying from microgram, milligram, to kilo bases of desired RNA molecule, based on template-directed techniques. RNA synthesis is one of the major fields on genetic research, personalized medicine, and many other techniques. Advancements in the field of biotechnology (including nanotechnology and molecular biology) have found diverse applications of in-vitro transcription templates for RNA synthesis, which have more clinical benefits than randomized DNA probes. It allows researchers and healthcare professionals perform various reactions to identify biochemical processes of the body. In-vitro transcription requires DNA-dependent RNA polymerase, templates, and transcription factors.
Rise in focus of health care and pharmaceutical companies in R&D, drug discovery, and gene editing has led to increase in demand for new and advanced transcription techniques to introduce new products and drugs in the pharmaceutical industry. This, in turn, is driving the global In-Vitro Transcription Templates Market during the forecast period. Rise in adoption of personalized medicine by health care providers is expected to increase demand for in-vitro transcription templates. Introduction of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing technology, enabling targeted medicine using RNA to bind to specific targets, and increase in incidence of rare diseases are some drivers of the global in-vitro transcription templates market during the forecast period. However, requirement for large capital investment deters new entrants from entering the market. This has increased the bargaining power of manufacturers and is leading to high cost of the in-vitro transcription templates and restraining the adoption and subsequent expansion of the global in-vitro transcription templates market.
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The global in-vitro transcription templates market is segmented on the basis of product type, application, end-user, and region. Based on product type, the global market is dived into plasmids, polymerase chain reaction (PCR) based products, oligonucleotides, and cDNA templates. The plasmids segment dominated the global in-vitro transcription templates market in 2017, owing to higher adoption of plasmids as templates by end-users. However, oligonucleotides segment is anticipated to expand at a considerable CAGR from 2018 to 2026.
Expansion of the segment can be attributed to increase in application in research, therapeutics, and diagnostics of oligonucleotide templates. Base on application, the global in-vitro transcription templates market is segmented into drug discovery, structural studies, biochemical and genetic studies, and others. The drug discovery segment dominated the global market in 2017. In terms of end-user, the global in-vitro transcription templates market is segregated into contract research organizations (CROs), pharmaceutical and biotechnology companies, academic & research institutes, and others. The pharmaceutical and biotechnology companies segment is expected to dominate the global market in 2017 due to high R&D focus and expenditure.