The scientific community has expended efforts and money in evaluating the efficacy of vascular grafts in reconstructive surgery. Wide range of grafting procedures including peripheral, aortic, and vascular access procedures put massive demands on graft manufacturers. Industry players ceaselessly toil over overcoming graft failure and rejection in patients. Stridently, their efforts have bore fruit evident in the expanding array of synthetic grafts as well as utilizing naturally derived materials, reinforcing the vascular graft market growth prospects.
Novel Tissue Engineering Approaches Improve Lives of Patients with CVD
In the past three decades, vascular reconstructive surgeries have seemingly become complex. Worryingly, autologous and synthetic graft transplantations have fallen short of patient expectations. Myriad clinical factors have evoked interest of human clinical trials in overcoming the limitations, as a deep dive on the vascular graft market analysis has found.
Small-Diameter Vascular Graft Engineering Gather Traction in Reconstructive Surgeries
Beyond doubt, cardiovascular diseases in adults pose glaring health burden: the mortality of coronary artery disease (CAD) and peripheral artery disease (PAD) is high. A slew of tissue engineering approaches are garnering attention of industry players. State-of-the-art manufacturing methods notably employ novel tissue engineering approaches in vascular graft production. Companies who have unveiled new designs and materials in tissue‐engineered vascular grafts have become optimistic of increasing vascular graft market share. Of note, small-diameter vascular grafts (SDVGs) need special mention in meeting advanced criteria in current grafting procedures in vascular graft market.
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The drive for finding and evaluating new therapeutic approaches in CVD is high. Newer grafts will gain clinical utility especially small-diameter vascular grafts gathering traction in complex reconstructive surgeries. This certainly opened up revenue streams for vascular graft market key players. The size of the market is projected to reach US$ 4.7 Bn in 2031, found a business intelligence study.
Improved Biocompatibility of Grafts Enter into Challenging Vascular Surgery Applications
With the use of SDVGs estimated to increase in bypass surgeries, popularly coronary artery bypass grafting (CABG), R&D in small-diameter vascular graft engineering approaches are poised to shape the evolution of the vascular graft market. Worldwide, the number of bypass surgeries has increased strikingly, including multiple surgeries. This aside, functional tissue-engineered vascular grafts (TEVGs) with attractive patency rates have led to emphasis on increasing the characteristics of synthetic conduits, among other things.
State-Of-The-Art Techniques for Vascular Graft Production Extending Horizon
Slew of New Manufacturing Techniques Enriching Outlook of Vascular Graft Market
Continuous research into evaluation of graft production techniques has led to high quality products in the vascular graft market. Nevertheless, in spite of the massive efforts, risks of graft failure and rejection in vascular reconstructive surgeries are in no way trivial. A number of synthetic and natural graft materials have been combined to improve biomechanical properties. Also, a spate of scaffold fabrication methods particularly electrospinning technology has grown in adoption. Moreover, companies in the vascular graft market are exploring the use of decellularized natural matrices and 4D printing especially for SDVGs. Surprisingly enough, not many have passed through animal models to human clinical trials.
Companies Combine Synthetic & Natural Materials to Overcome Limitations of Current Implants
Depending on different arterial environments and the nature of vascular surgeries, product pipeline of the vascular graft market is stridently expanding. In addition to this, pediatrics population presents a vast avenue, mainly due to limited growth ability in these patient cohorts.
Tens of scores of tissue-engineered vascular grafts (TEVGs) focus on biodegradable polymers. Some of the most commonly used synthetic grafts are made of PGA Poly (glycolic acid) polymers. A number of naturally occurring polymers are also attracting vascular graft market key players.
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Ongoing studies on adapting to TEGV techniques will improve patient care in CVDs and eventually reduce the health and economic burden. However, translating these from bench to bedside is easier said than achieved.
To improve biodegradation profiles of the current array of the products in the vascular grafts, an approach that merits attention is combining natural biomaterials with biodegradable synthetic polymers. Such vascular grafts are being extensively studied in small animal models.
All said and done, the most important set of criteria for commercialization of tissue engineered vascular grafts is the troika of ease of handling, cost-effectiveness, and easy availability of the products. Hence, the vascular graft market will witness players increasingly focusing on these to keep reaping revenues from their existing product portfolio for a long time.