Using Protein Therapy to Accelerate Healing Post Heart Attack

Researchers have developed a new method to enhance the healing power of the heart post a heart-attack. The research was conducted by the Westmead Institute for Medical Research (WIMR), in collaboration with the University of Sydney. The researchers point to the ability of protein therapy, involving human platelets, as a sound contributor to healing. Use of recombinant human platelet-derived growth factor-AB (rhPDGF-AB) could enhance outcomes following heart attacks. The findings of the research open new avenues for advancements within the field of cardiology. Science Translational Medicine journal published the findings of the research.

 Development and Effect of Scar Tissues

Scar tissues formed after a heart attack adversely affect the functioning of the heart. Meanwhile, researchers assert that infusion of rhPDGF-AB could help in improving the quality of the scar. Furthermore, this also induces the development of fresh blood vessels in the heart. The risk of heart arrhythmia can be reduced through infusion of rhPDGF-AB in the body. Patients suffering from heart arrhythmia experience irregular heart rhythms, and this can be fatal in the long-run.

 The lead researcher states unavailability of treatment for scars developed after a heart attack. The research in question is in the pre-clinical stage, and could be the first to impact scar health. The researchers explain that improvements in cardiac function and scar health could increase survival rate during heart attacks.

 Increasing Strength of Scars

During research, infusion of rhPDGF-AB did not increase the size of scar. However, it did cause the scar to undergo fiber alignment and acquire greater strength. These changes led to improvements in heart functionality, and subsequently accelerated the process of healing. Researchers used mouse models to show improvements in heart help through protein therapy. They claim to have compelling data to prove the veracity of their assertions.