Developing Insulin Analogues for Improved Treatment of Diabetes

A team of researchers has developed a new method for improved insulin delivery. The research was pioneered at the Florey Institute of Neuroscience and Mental Health. Clinical delivery of insulin holds immense relevance in treatment of diabetes. Therefore, development of a non-fibrillating method for insulin dosage shall improve the healthcare index. Meanwhile, researchers used a novel glycosylation technique to develop an insulin analogue. The analogue produces same effect on glucose levels as native insulin, with the former named glycoinsulin. Preclinical studies have proven the effectiveness of glycoinsulin in lowering glucose levels. Moreover, prevention of fibril formation through glycosylation helps in proper administration of insulin. Formation of fibrils can block pathways traced for insulin delivery, which can in turn become fatal.

 Understanding Action of Glycoinsulin

 It is important to prevent under dosing of insulin, and this makes it necessary to inhibit aggregation of insulin fibrils. Lead researchers believe that glycoinsulin offers premium solutions for treating diabetes. The ability to prevent fibril formation at even high temperatures points to the utility of glycoinsulin. Moreover, this insulin analogue acquires increased stability inside the human body as against native insulin. Therefore, glycoinsulin finds use as an excellent product for usage inside insulin pumps. Moreover, glycoinsulin can also come in handy in increasing the shelf life of other insulin products.

 Future of Clinical Trials

 The researchers intend to test the effectiveness of glycoinsulin for several other applications. Therefore, clinical trials are expected to lay their focus on investigating this compound. Use of insulin pumps for diabetes management is a common practice across the US and Australia. This trend has helped researchers in popularising glycoinsulin, and its potential uses. Supremacy of glycoinsulin over insulin pump infusion sets shall be the focal point of market research.