How Isolation Techniques Can Protect Heart Tissues during Heart Attacks?

A research study in the Journal of the American Heart Association, reveals a potential use for heart tissues. The research was aimed at preventing heart tissues from collapsing during heart attacks. Scientists from the Fralin Biomedical Research Institute studied various compounds to evaluate their shielding action during heart attacks. And, they discovered a special compound that may protect heart tissues from severe damage. The compound is capable of preserving healthy cells in the heart tissues. 

Understanding Potential Damage 

Heart attack can severely damage muscle tissues. The new compound helps restore health of the heart tissues. Time plays an important role in maintaining health of the heart cells in the event of an attack. Further, heart cells die when blood supply is cut-off for long. Blood supplied to the heart contains oxygen that rejuvenates the heart cells. Reduced blood supply to isolated parts of the heart cell results in a condition called hypoxic ischemic injury. Moreover, the dying heart cells are capable of sending signals to other healthy cells. This aggrandizes the problem, and magnifies the damage caused to heart tissues.

Managing Heart Attacks to Alleviate Damage

Communication of damaged cells with healthy cells causes “Bystander effect”. Hence, the scientists identified the need to quarantine an area where the dying cells cannot send signals from. This could help in ensuring that the neighbouring cells remain unaffected by the dying cells. The molecule developed by the scientists localizes the group of dying cells to prevent other cells. The medical research industry has made several attempts to dilute the bystander effect.

The research may open new avenues for managing heart attacks. Furthermore, other entities and medical centers are also expected to take inspiration from the findings to conduct further research.

Painkillers Can Lead to Heart Attacks, Find Researchers

As per a Canadian study, the seemingly innocuous common painkillers can be dangerous as they can up the risk of a heart attack. Such common painkillers are referred to as NSAIDs, acronym for non-steroidal anti-inflammatory drugs. The study reveals that NSAIDs like ibuprofen, celecoxib, diclofenac, and naproxen that are easily available over the counter or by prescription for higher doses can increase the risk of a heart attack or stroke by about 20 percent to 50 percent on an average. Such medicines are administered for curing minor pains, flu, back pain, and menstrual cramps.

Any Dosage of Drugs up Risk

In the research study conducted by Michèle Bally and her team from the University of Montreal Hospital Research Centre, Canada, findings from 446,763 people, with 61,460 of them having had a heart attack, gleaned from Canadian and European databases, were examined. The aim was to assess the risk, determinants and time course of heart attacks associated with the use of NSAIDs under typical circumstances.

Michèle Bally and her team of researchers found that any dosage of these drugs for a week, a month, or longer was associated with an increased risk of a heart attack. The risk seemed to wane once the painkillers were discontinued. While the first 30 days after discontinuation saw a small decline, in the period after that and one year saw a greater decline of under 11 percent.

There have been previous research in this direction too linking NSAIDs with heart attacks known as myocardial infarction. However, specific details in terms of timing, dosage, and treatment durations were less clear.