Study identifies genes associated with human senescence

In cellular biology, cellular senescence, is recognized as a stamp of authenticity and basic driver of organismal aging. In fact, as per scientific knowledge, cellular senescence is regulated by epigenetic as well as genetic factors.

And, so far, only a handful of genes associated with aging have been reported. Furthermore, the identity and roles of additional genes associated with regulating human cellular aging remain undiscovered. Hitherto, there remains lack of systematic investigation on intervention of these genes to treat aging and aging associated disorders.

Meanwhile, there are several questions pertaining to aging in the human gene that remain unanswered. How many genes are present that promote aging in the human genome? What are the molecular mechanisms via genes regulate aging? Can gene therapy mitigate individual aging? In this context, a team of researchers at the Chinese Academy of Sciences shed new light on the role of genes in regulating aging.

Study leads to new therapeutic approach in aging pathology

Recently, researchers at the Institute of Zoology, Chinese Academy of Sciences and Beijing Institute of Genomics also of the Chinese Academy of Sciences have collaborated to discover new genes that promote human senescence. The team carried this out by using a genome-wide CRISPR/Cas9 screening system in order to provide a new therapeutic approach to treat aging and aging-related pathologies.

For the study, researchers carried out genome-scale CRISPR/Cas9-based screening to comprehend premature aging of human stem cells, and discovered more than 100 gene candidate that promote senescence. In addition, the researchers verified how the top 50 gene candidates are effective to promoting cellular rejuvenation employing targeted sgRNAs.

As a result of this, KAT7 identified as one of the top targets for alleviating cellular senescence.

Human Intelligence Explained through Number of Genes in New Study

What impacts the level of human intelligence has always been a debatable topic for decades now. A new study conducted by almost 80,000 people and published by Nature Genetics, managed to identify the number of genes that are likely to be involved in influencing the level of intelligence level of a person. Intelligence’s dictionary definition is the capability to understand, learn, or deal with situations logically. Humans as well as animals display various forms of intelligence, generally critical for endurance. Human intelligence initially started as being “reactive” and then reached out to be “proactive”. After the initial challenge of survival was addressed, humans turned to employ their intelligence towards the development higher skills related to technology and arts.

Briefing the Experiment

The new study employed known as “g-factor” for measuring intelligence. The g-factor is considered one of the most unbiased methods used for scientific research at present. The researchers examined the scores of 78,000 people of Europe in order to look for genes and associated genetic factors that hypothetically influence the human intelligence. The genome-wide association study or the (GWAS) was carried out to assess links between SNPs and a particular trait. This specific enabled the scientists to identify almost 336 noteworthy SNPs.

What was the ultimate outcome of the study?

The scientists involved in the project revealed that the strongest genes were actually linked to intelligence and are also involved in the pathways that play a crucial part in the administration of the development of the nervous system. The most important SNP was discovered inside FOXO3, a form of gene that is involved in the process of insulin signaling and the strongest gene was CSE1L, the gene involved in cell proliferation and apoptosis.

Henceforth, this paper initially suggests that human intelligence relies on the molecular mechanisms that aid in the preservation and development of the human nervous system and intelligence can be explained through genetics.