Physicians today face numerous issues in their aim of providing top-notch healthcare services to patients. Detecting diseases at their early stages is one of the present critical issues that prompted scientists to focus on latest biomarkers such as microRNAs. Moreover, the present researches highlight the link between microRNA levels in biological liquids and various diseases such as a few cancer types. But the key problem in microRNA molecules is they are diluted and very short. This situation prompts for an exceptionally sensitive technique to spot and quantify microRNA.
A Reprogrammable Molecular Circuit
Researchers from the University of Paris and Gulliver Laboratory at ESPCI Paris (PSL University) recently announced their collaboration. The main motive of this collaboration was to find out a novel technique that can spot and quantify microRNAs. The outcomes of their research offered a probable answer for the issue: a molecular circuit, which is reprogrammable. Reportedly, this circuit will allow for particularly microRNA quantification. Moreover, the research is open to access in the journal Science Advances.
The main focus of Yannick Rondelez—the research lead—and his associates at the Gulliver lab of ESPCI Paris was to find out the biochemical network reactions to complete complicated tasks. The research team worked on the fundamental concept and transformed the data into a molecular circuit. The specialty of this circuit is that it can detect, amplify, and signal the microRNA presence with the help of fluorescence. For liquid biopsies, the latest test uses a dynamic threshold, which helps in avoiding the false-positive test results.
Guillaume Gines, the co-author of this study, stated, “The outcomes of this study are very promising. Moreover, the subsequent step in this study will be to authenticate our technique in a clinical frame together with patients’ liquid biopsies.” The latest technique has been patented and is easily re-programmable. Furthermore, it offers adaptability for the detection to some interesting microRNA.