In a recent study, researchers have developed a new diagnostic approach to understand bladder cancer through a urine sample. Researchers at the School of Medicine developed a sensitive urine test for monitoring and diagnosing bladder cancer. Study’s findings were published in Cancer Discovery journal. Maximilian Diehn, Ash Alizadeh, Jonathan Dudley, MD, and Joseph Schroers-Martin are the lead authors of the study. The objective of the study is to look for the remains of cancer DNA in urine samples.
Study Resulted in Detecting Cancer in its Early Stages
In the United States, more than 80,000 people are diagnosed with bladder cancer each year. It is the sixth most common cancer seen in people. Currently, cystoscopy is the most accurate method to diagnose bladder cancer. Another way of looking for cancer cells in urine through cytology test.
Based on previous studies co-authored by Alizedah and Diehn showed that certain cancers can be detected by looking for DNA fragments of tumors flowing in the bloodstream. This is carried out by a method known as CAPP-Seq (Cancer Personalized Profiling by Deep Sequencing). In this study, the researchers changed bioinformatics and molecular aspects of this technique to relate in bladder cancer DNA remains found in urine.
This study helped in testing bladder cancer through urine, they could also detect cancer in its early stages when it can be treated more easily. Researchers were able to identify the presence of bladder cancer in 83% of patients having early-stage bladder cancer, which was 14% through a urine cytology test.
The most astonishing thing is that the researchers could detect the recurrence of bladder cancer after the treatment.