A team of researchers at the Johns Hopkins University have successfully tested a new drug formulation on mice that may be able to reverse the disorders caused by fatty and high cholesterol diets such as hair whitening, hair loss, and skin inflammations. The investigation has landed up to a compound that can halt the production of specific fats that are responsible for the disorders, known as glycosphingolipids or similar GSLs.
These components are essential for the cell membranes in the skin. Recent researches have shown that subjecting mice to high cholesterol and fatty diets can cause hair discoloration to gray or white from black. Also, hair loss and wounds emerged as symptoms. Although the new compound seems to be working on mice, there is no guarantee of its positivity on humans. Nevertheless, this certainly opens possibilities with further research and promises to work for the patients suffering from psoriasis as well as wounds as a result of plastic surgery or diabetes.
A number of past studies have showcased that glycosphingolipids present in the cells and made for the top layer of our skin. Moreover, they are available in cells named as keratinocytes that is responsible in regulating the pigmentation of the hair, eyes, and skin.
The researchers used mass spectrometry analysis in order to identify as well as quantify the chemical compositions of the novel mixture, determining the content of lactosylceramide, ceramide, and glucosylceramide. The next step in the research is to study the effects on other animals and find out what amounts of D-PDMP can heal wounds.