Glioblastoma multiforme (GBM) is a high-grade gliomas and the most malignant astrocytic tumor, composed of complexly differentiated neoplastic astrocytes, a subtype of central nervous system (CNS). Glioblastoma is clinically classified as grade IV astrocytoma and differs from anaplastic astrocytoma (grade III) due to the presence of necrotic tissue and hyperplastic blood vessels. The diagnosis of GBM is carried out with imaging modules such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). In case of GBM treatment, there are many restraints and challenges such as its resistance against DNA-modifying agents, migration of malignant cells into adjacent brain tissues increases the complexity of the surgery, and current FDA approved treatments may cause neurotoxicity in patients. Thus, as available treatment options lack in efficiency, the mortality rate of glioblastoma is characterized by rapid progression and poor survival rate with only 8.7% of the patients surviving more than two years post diagnosis. According to Centers for Disease Control and Prevention (CDC), in 2011, approximately 22,000 adults in the U.S. were diagnosed with primary malignant tumors of the brain and spinal cord out of which gliomas accounted for the highest rate of incidence.
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Glioblastoma multiforme (GBM) is the most lethal and common brain tumor in adults. The treatment modalities available in the market at present include surgical resection, followed by radiotherapy and chemotherapy. Despite being around in the healthcare industry since the last few years, these modalities have done little to decrease the overall mortality rate in patients. Recurrence of disease, glioma stem cell resistance to conventional modalities, and invasiveness of GBM are a few factors hampering the success rate of available treatment methods.
Novel treatment strategies are, therefore, desperately required to address such unmet medical needs, and the GBM pipeline already includes a mix of small molecules, immunotherapy, biological, and other types of therapeutics. Advances introduced in gene technology and molecular biology also provide lucrative novel possibilities for efficient treatment of patients diagnosed with GBM. The report discusses the aforementioned factors in detail as the most crucial growth drivers of the glioblastoma treatment market.
Some of the glioblastoma treatments approved by the FDA include bevacozumab, temozolomide, and carmustine. Of these, carmustine, known by the brand name Gliadel (a product of Arbor Pharmaceuticals, LLC), is surgical implant. Likewise, bevacozumab, brand named Avastin by Genetech/Roche, is used for intravenous therapy and temozolomide (brand named Temodal/Temodar/Temcad) is primarily recommended for oral or intravenous chemotherapy. The report analyzes the market dynamics of these available drugs and therapies. It also studies their effectiveness in glioblastoma treatment to measure the scope for novel therapies.