Poly (ADP-ribose) polymerase (PARP) is implicated in intracellular DNA repair pathways. PARP1/PARP2 have been extensively studied. A number of molecules have been developed as PARP inhibitors which are mainly associated with their PARP-trapping efficiency. They are preferentially killing cancer cells in BRCA-mutation cancer cell lines. PARP inhibitors play key role in increasing cytotoxicity. The growing market proposition for excitement over PARP inhibitors owing to their potential in triple negative breast cancer. These molecules are growing in clinical relevance in BRCA1- or BRCA2-associated ovarian or breast cancers, and they are being used in conjunction with chemotherapy. A growing body of research in PARP inhibitors development has been spurring the strides in the PARP inhibitors market.
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Growing Research on BRCA-mutation Tumors Pave Way to Lucrative Avenues for Drugmakers
A number of PARP inhibitors are being developed. The growing demand for targeted therapy for ovarian cancer is adding force to these developments. BRCA-mutation tumors have been extensively being studied. Growing studies on exploiting the synthetic lethality of synthetic lethality has augmented the prospects of PARP inhibitors in oncology. A number of in vitro studies and studies involving in xenograft models of PARP inhibitors in in BRCA-associated tumors. Cytotoxic therapy is expected to see new attention.
Olaparib (Lynparza), niraparib (Zejula), and rucaparib (Rubraca) are some of the PARP inhibitors in treating advanced ovarian cancer.
On the regional front, Asia Pacific is a remarkably lucrative market. The growth of the regional market has gathered momentum on the back of research on BRCA-mutation tumors. The growing research on ovarian cancer is also bolstering the prospects in the regional market. The awareness of morbidity of ovarian cancer has also generated new revenue potential for drug makers eyeing opportunities in the regional market. The growing demand for targeted drug therapies has bolstered the prospects in Latin America.
Some of the key players in the PARP inhibitors market are Clovis Oncology, Medivation, AbbVie Inc., Tesaro, and AstraZeneca.
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