In the dental sector, the root canal treatment is one of the highest dental procedure done. The dental surgery for root canal treatment leaves a dead tooth without leaving any living tissue or dental pulp. According to the new research, scientists have advanced a peptide hydrogel to provoke the growth of dental pulp and new blood vessels within a tooth after the treatment.
The results of the research are going to be present in at the National Meeting & Exposition of the American Chemical Society (ACS). As the tooth, left after the procedure is a dead tooth with no nerves ending or no vascular supply. In this case, the tooth is susceptible to get infection and falls out, says Vivek Kumar, project’s lead investigator.
During the root canal procedure, where gutta percha (tiny rubber rod) is filled, researchers are developing new material to replace the gutta percha. This material will be effective in stimulating angiogenesis (new blood vessels) and dentinogenesis (growth of dental pulp stem cells) inside the tooth.
On the basis of Kumar’s previous research, in which he used hydrogel to stimulate angiogenesis by injecting it under the skin of the rats. The hydrogel is in liquid state during injection and then turns into gel due to the presence of peptides, at the injection site. Vascular endothelial is present in peptides at a very small quantity and acts as a growth factor to develop new blood vessels. Kumar and his co-workers presented the self-assembling peptide hydrogel to provoke the growth of angiogenesis by using it on the rodent’s skin for three months.